Stattic from MedChemExpress

Product Specs
ItemStattic
CompanyMedChemExpress
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberHY-13818
TypeChemical
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Quantity5 mg
Purity98.92%

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MedChemExpress

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Monmouth Junction, NJ 08852

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Company Profile

Website: medchemexpress.com

(1) KDF1 Promoted Proliferation, Migration and Invasion of Lung Adenocarcinoma Cells through Activating STAT3 and AKT PathwayBiomedicinesDecember 1, 2023Yi-Qing Guo, Mei-Fu Gan, Jia-Qian Bao, Han-Xi Zhou, Jing Yang, Chuan-Jing Dai, Jing-Min Zhengused LY294002 (Cat.No HY-10108, MedChemExpress LLC, Monmouth Junction, NJ, USA) and Stattic (Cat.No HY-13818, MedChemExpress LLC, Monmouth Junction, NJ, USA) to inhibit the activation of the AKT and STAT3 pathway,

(2) Aryl hydrocarbon receptor regulates IL-22 receptor expression on thymic epithelial cell and accelerates thymus regenerationnpj Regenerative MedicineNovember 8, 2023Jingyi Shen, Ying Wang, Fei Zheng, Shuo Cao, Qiu Lan, Kailin Xu, Bin PanShanghai, China) containing 10% FBS for 72 h. Reagents FICZ (HY-12451), CH-223191 (HY-12684), stattic (HY-13818) and colivelin (HY-P1061A) were purchased from MedChemExpress (Monmouth Junction, NJ, USA). Recombinant murine IL-22

(3) CD36+ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factorCell DiscoveryMarch 6, 2023Gui-Qi Zhu, Zheng Tang, Run Huang, Wei-Feng Qu, Yuan Fang, Rui Yang, Chen-Yang Tao, Jun Gao, Xiao-Ling Wu, Hai-Xiang Sun, et al.1:1) without or with neutralizing ISO-1 (10 nM, #HY-P7387, MedChemExpress) and/or Stattic (100 nM, HY-13818, MedChemExpress) for 24 h, respectively. Uptake of fatty acids or lipoproteins, lipid peroxidation

(4) Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axisFrontiers in PharmacologyFebruary 3, 2023Huimin Ji, Hongliang Dong, Yuejiao Lan, Yuqian Bi, Xuan Gu, Yongyue Han, Chongyang Yang, Minghan Cheng, Jian GaoPharmaceuticals Co., Ltd. Metformin (Cat. No. D150959) was purchased from Sigma-Aldrich. Stattic (Cat. No. HY-13818) was obtained from MedChemExpress, and Recombinant Human TGF-β1 (Cat. No. 100-21) was purchased from

(5) Chronic inflammation decreases HSC fitness by activating the druggable Jak/Stat3 signaling pathwayEMBO reportsJanuary 9, 2023Srdjan Grusanovic, Petr Danek, Maria Kuzmina, Miroslava K Adamcova, Monika Burocziova, Romana Mikyskova, Karolina Vanickova, Sladjana Kosanovic, Jana Pokorna, Milan Reinis, et al.below: Stattic treatment Stattic (Stat3 inhibitor) was purchased from MedChemExpress (catalog #: HY‐13818). WT and CMO mice were injected intraperitoneally with PBS control or Stattic (20 mg/kg). A total of

(6) Ezh2Y641F mutations co-operate with Stat3 to regulate MHC class I antigen processing and alter the tumor immune response in melanomaOncogeneNovember 11, 2022Sarah M. Zimmerman, Samantha J. Nixon, Pei Yu Chen, Leela Raj, Sofia R. Smith, Rachel L. Paolini, Phyo Nay Nay Lin, George P. Souroullas(InVivoMAb anti-mouse CD8β Cat# BE0223 Lot# 733219O1) and Stat3 inhibitor STATTIC (MedChemExpress Cat# HY-13818 Batch# 21868) were administered intraperitoneally at 10 mg/kg. For flow cytometry analysis, tumors were

(7) IL-20RB mediates tumoral response to osteoclastic niches and promotes bone metastasis of lung cancerThe Journal of clinical investigationOctober 17, 2022He Y, Luo W, Liu Y, Wang Y, Ma C, Wu Q, Tian P, He D, Jia Z, Lv X, et al.protein was from Peprotech (catalog 200-19-10). The STAT3 inhibitors napabucasin (HY-13919) and stattic (HY-13818) were obtained from MedChemExpress. The ELISA kits used were as follows: GM-CSF (Proteintech; KE00003

(8) Intestinal epithelial cell autophagy deficiency suppresses inflammation-associated colon tumorigenesisMolecular Therapy - Nucleic AcidsJune 14, 2022Hao Liu, Jun Lou, Yunlong Liu, Zhen Liu, Jiansheng Xie, Jiachun Sun, Hongming Pan, Weidong Hanresults were calculated in pg/mL. Stattic treatment The STAT3 inhibitor stattic (MedChemExpress, Cat# HY-13818) was dissolved in vehicle (10% DMSO, 40% PEG300, 5% Tween-80, 45% saline) followed by intraperitoneal injection

(9) Blocking STAT3 signaling augments MEK/ERK inhibitor efficacy in esophageal squamous cell carcinomaCell death & diseaseMay 25, 2022Zheng ZY, Chu MY, Lin W, Zheng YQ, Xu XE, Chen Y, Liao LD, Wu ZY, Wang SH, Li EM, et al.(V1121) was purchased from Promega. Trametinib (MEK1/2 inhibitor, HY-10999), Stattic (STAT3 inhibitor, HY-13818), and ruxolitinib (JAK1/2 inhibitor, HY-50856) were obtained from MedChemExpress (MCE, China). Blasticidin

(10) IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylationNature communicationsJune 15, 2021Hu F, Song D, Yan Y, Huang C, Shen C, Lan J, Chen Y, Liu A, Wu Q, Sun L, et al.different experiments. Chloroquine (CQ; Cat#C6628) was obtained from Sigma. Inhibitors of STAT3 (Stattic, HY-13818) and JAK2 (CHZ868, Cat# HY-18960) were purchased from MedChemExpress. 5-Fluorouracil (5-Fu; Cat#F6627),

(11) Berberine suppresses bladder cancer cell proliferation by inhibiting JAK1-STAT3 signaling via upregulation of miR-17-5pBiochemical PharmacologyJune 1, 2021Yangyang Xia et al.5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT, #M2128) were purchased from Sigma (St. Louis, MO, USA). Stattic (#HY-13818) was purchased from MedChemExpress (Monmouth Junction, NJ, USA). Berberine chloride and stattic were dissolved

(12) A Positive Feedback Loop of lncRNA DSCR8/miR-98-5p/STAT3/HIF-1α Plays a Role in the Progression of Ovarian CancerFrontiers in OncologySeptember 2, 2020Lina Dong, Xuejiao Cao, Yi Luo, Guoqing Zhang, Dandan ZhangmiR-98-5p in cells. signal transducer and activator of transcription 3-specific inhibitor Stattic (Cat. No. HY-13818) and HIF-1α specific inhibitor BAY 87-2243 (Cat. No. HY-15836) were purchased from MedChemExpress (Shanghai,

(13) Crocin has pharmacological effects against the pathological behavior of colon cancer cells by interacting with the STAT3 signaling pathwayExperimental and Therapeutic MedicineDecember 16, 2019Jun Wang, Yupei Ke, Tao Shu(Thermo Fisher Scientific, Inc.) at 37˚C and 5% CO2. Prior to western blot analysis, HCT116 cells were treated with Stattic (HY‑13818; MedChemExpress), according to the manufacturer's instructions, to inhibit the activity of the STAT3

(14) JAK3/STAT3 oncogenic pathway and PRDM1 expression stratify clinicopathologic features of extranodal NK/T‑cell lymphoma, nasal typeOncology ReportsApril 12, 2019Jumei Liu, Li Liang, Dong Li, Lin Nong, Yalin Zheng, Sixia Huang, Bo Zhang, Ting Li14703; Cell Signaling Technology, Inc., Danvers, MA, USA) and Stattic (1, 2, 5 and 10 µM) (cat. no. HY-13818; MedChemExpress, Inc., Shanghai, China) at indicated concentrations for 24 and 48 h, with dimethyl sulfoxide

(15) Interleukin 22 Expands Transit-Amplifying Cells While Depleting Lgr5⁺ Stem Cells via Inhibition of Wnt and Notch SignalingCellular and molecular gastroenterology and hepatologyJanuary 1, 2019Zha JM, Li HS, Lin Q, Kuo WT, Jiang ZH, Tsai PY, Ding N, Wu J, Xu SF, Wang YT, et al.(Merck Millipore, Burlington, MA; 420099) or STAT3 inhibitor Stattic (MedChemExpress, Monmouth Junction, NJ; HY-13818) was added to ENR medium. Images were collected by using an inverted microscope (Olympus IX-73, Tokyo,

(16) Nerve growth factor (NGF)-treated nitrocellulose enhances and directs the regeneration of adult rat dorsal root axons through intraspinal neural tissue transplantsNeuroscience lettersAugust 14, 1989Houle JD, Johnson JE.

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